Manchester United welcome back Morgan Schneiderlin in place of Marouane Fellaini for the trip to Sunderland.
Louis van Gaal has made just one change from the team that came within minutes of victory over Chelsea, with goalscorer Jesse Lingard keeping his place.
The hosts, who came from 2-0 down to draw with Liverpool last time out, have made two changes, bringing in DeAndre Yedlin and new signing Dame N’Doye for Billy Jones and Duncan Watmore.
Victory for Sunderland would lift them above Norwich, at least until this afternoon when the Canaries take on West Ham at Carrow Road.
With the top four facing off tomorrow, defeat for United could potentially leave them seven points off the top four at the end of the weekend.
The visitors won the reverse fixture by three goals to nil, and will be hoping for a repeat at the Stadium of Light.
#SAFCXI v @ManUtd: Mannone, Yedlin, O’Shea, Kone, van Aanholt, Kirchhoff, Cattermole, M’Vila, Khazri, N’Doye, Defoe. pic.twitter.com/VtkcIJNWeP
— Sunderland AFC (@SunderlandAFC) February 13, 2016
#mufc XI: De Gea, Darmian, Smalling, Blind, Borthwick-Jackson, Schneiderlin, Carrick, Lingard, Mata, Martial, Rooney pic.twitter.com/ukmWfoNeOH
— Manchester United (@ManUtd) February 13, 2016